On May 13th 1919 the Permanent Epidemic Commission of the Ministry of Health was founded and that gave rise to organized supervision of hygienic conditions and infectious diseases in the Kingdom of Serbs, Croats and Slovenes. The first president was Milan Jovanovic Batut DScMed.
In 1922–1923, the Bacteriological Station in Belgrade, the Laboratory for Tropical and Parasitic Diseases, and the Institute for Social Medicine were founded as the nucleus of the future Central Institute for Hygiene.
In 1924 the Central Institute for Hygiene was founded.
In 1945, after the end of the Second World War, the following institutions were located in the building of the Central Institute of Hygiene hosted: the Federal Epidemiological Institute, the Federal Institute of Hygiene and the Bacteriological and Epidemiological Institute of Serbia
In 1951 the Institute of Hygiene of the People’s Republic of Serbia was founded.
In 1961, the Institute of Hygiene of the PR of Serbia became the Institute for Health Care of the Socialist Republic of Serbia and was entrusted with the function of the Republic Health Center.
In 1979, the Institute for Health Care of the PR of Serbia became the Institute for Health Care of Serbia ‘’Dr Milаn Јоvаnоvic Bаtut".
In 1997, it changed to the Institute of Health of Serbia ‘’Dr Milаn Јоvаnоvic Bаtut".
In 2006, it became the Institute of Public Health of Serbia ‘’Dr Milаn Јоvаnоvic Bаtut’’.